S (continued)
- Sengoku Denshou
- Sexy Parodius
- Shadow Blasters
- Shadow Dancer
- Shadow Hearts
- Shadow of the Colossus
- Shadow of the Ninja
- Shadowgate
- Shadowrun
- Shadowrun (SNES)
- Shatterhand
- Shien's Revenge
- Shienryu
- Shining in the Darkness
- Shining Wisdom
- Shinobi
- Shinobi III - Return of the Ninja Master
- Shinobi Legions
- Shinobi: Art of Vengeance
- Shufflepuck Café
- Shui Hu Feng Yun Zhuan
- Silent Assault
- Silent Bomber
- Silent Hill
- Silent Hill 2
- Silent Hill 3
- Silhouette Mirage
- Silkworm
- Silpheed
- Silpheed: the Lost Planet
- Silver
- Silver Eagle
- Silver Surfer
- Skeleton Krew
- Sky Shark
- SkyBlazer
- Sküljagger - Revolt of the Westicans
- Slave Zero
- Smash T.V.
- Snake Rattle 'n' Roll
- Snatcher
- Snow Bros
- Snow Bros. starring Nick and Tom
- Socket
- Sol Divide
- Sol-Deace
- Soldiers of Fortune
- Solomon's Key
- Sonic Blast Man
- Sonic Blast Man II